Unit GENERAL BIOLOGY AND GENETICS
- Course
- Medicine and surgery
- Study-unit Code
- GP001255
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Vincenzo Nicola Talesa
- CFU
- 7
- Course Regulation
- Coorte 2021
- Offered
- 2021/22
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
GENERAL BIOLOGY AND GENETICS - MOD. 1
| Code | A001679 |
|---|---|
| Location | PERUGIA |
| CFU | 6 |
| Teacher | Vincenzo Nicola Talesa |
| Teachers |
|
| Hours |
|
| Learning activities | Base |
| Area | Discipline generali per la formazione del medico |
| Academic discipline | BIO/13 |
| Type of study-unit | Obbligatorio (Required) |
| Language of instruction | Italian |
| Contents | Cell Cycle. Formal genetics. Medical genetics. Blood types genetics. Recombinant DNA technology. |
| Reference texts | Biologia e genetica - G. De Leo, E. Ginelli - S. Fasano Edises |
| Educational objectives | The aim of the course is the integrated study of the cell and living organisms, with emphasis on cell cycle, mutations, general and human genetics, recombinant DNA technology. The ability to learn, relate and integrate one concept to another will be considered fundamental in order to facilitate the understanding of the disciplines provided in the subsequent years of the Degree Course. |
| Prerequisites | Basic elements of cellular and molecular biology |
| Teaching methods | Face-to-face |
| Other information | Site of the teacher Nuova sede dei Dipartimenti di Medicina - Edificio B- 4° piano - P.le L. Severi 1 - Sant'Andrea delle Fratte - Perugia |
| Learning verification modality | Oral examination |
| Extended program | Euploid human karyotype. Cell cycle: interphase and phase M. Sexual reproduction and gametogenesis. Pathological human karyotype (genomic mutations). Gene and chromosomal mutations. Spontaneous and induced mutations. Somatic and germline mutations. DNA repair mechanisms. Cell death mechanisms. Basic elements of formal genetics: allele, haploid and diploid organisms, genotype, phenotype, homozygous and heterozygous organisms, dominance, recessiveness, Mendel's laws and extensions to Mendelian analysis (incomplete dominance, codominance, multiple alleles). Basic concepts of medical genetics: family trees, dominant and recessive autosomal inheritance, sex-linked inheritance (X-linked and Y-linked). Multifactorial and polygenic inheritance. Mitochondrial inheritance. Pleiotropy. Epistasis. Expressivity and penetrance. Blood types genetics. Recombinant DNA technology and its main applications: purification and electrophoresis of nucleic acids, gene cloning (restriction enzymes and vectors), genomic and expression libraries, PCR, Real time PCR. Applications: genetic diagnosis of diseases, diagnosis of pathogenic infections, medico-legal investigations, gene therapy, GMOs. |
GENERAL BIOLOGY AND GENETICS - MOD. 2
| Code | A001680 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Teacher | Cinzia Antognelli |
| Teachers |
|
| Hours |
|
| Learning activities | Base |
| Area | Discipline generali per la formazione del medico |
| Academic discipline | BIO/13 |
| Type of study-unit | Obbligatorio (Required) |
| Language of instruction | Italian |
| Contents | Cell Cycle. Formal genetics. Medical genetics. Blood types genetics. Recombinant DNA technology. |
| Reference texts | Biologia e genetica - G. De Leo, E. Ginelli - S. Fasano Edises |
| Educational objectives | The aim of the course is the integrated study of the cell and living organisms, with emphasis on cell cycle, mutations, general and human genetics, recombinant DNA technology. The ability to learn, relate and integrate one concept to another will be considered fundamental in order to facilitate the understanding of the disciplines provided in the subsequent years of the Degree Course. |
| Prerequisites | Basic elements of cellular and molecular biology |
| Teaching methods | Face-to-face |
| Other information | Site of the teacher Nuova sede dei Dipartimenti di Medicina - Edificio B- 4° piano - P.le L. Severi 1 - Sant'Andrea delle Fratte - Perugia |
| Learning verification modality | Oral examination |
| Extended program | Euploid human karyotype. Cell cycle: interphase and phase M. Sexual reproduction and gametogenesis. Pathological human karyotype (genomic mutations). Gene and chromosomal mutations. Spontaneous and induced mutations. Somatic and germline mutations. DNA repair mechanisms. Cell death mechanisms. Basic elements of formal genetics: allele, haploid and diploid organisms, genotype, phenotype, homozygous and heterozygous organisms, dominance, recessiveness, Mendel's laws and extensions to Mendelian analysis (incomplete dominance, codominance, multiple alleles). Basic concepts of medical genetics: family trees, dominant and recessive autosomal inheritance, sex-linked inheritance (X-linked and Y-linked). Multifactorial and polygenic inheritance. Mitochondrial inheritance. Pleiotropy. Epistasis. Expressivity and penetrance. Blood types genetics. Recombinant DNA technology and its main applications: purification and electrophoresis of nucleic acids, gene cloning (restriction enzymes and vectors), genomic and expression libraries, PCR, Real time PCR. Applications: genetic diagnosis of diseases, diagnosis of pathogenic infections, medico-legal investigations, gene therapy, GMOs. |