Unit PHARMACEUTICAL ANALYTICAL CHEMISTRY II
- Course
- Chemistry and technology of drugs
- Study-unit Code
- 65418308
- Location
- PERUGIA
- Curriculum
- In all curricula
- Teacher
- Emidio Camaioni
- Teachers
-
- Emidio Camaioni
- Roccaldo Sardella (Codocenza)
- Hours
- 150 ore - Emidio Camaioni
- 2 ore (Codocenza) - Roccaldo Sardella
- CFU
- 8
- Course Regulation
- Coorte 2018
- Offered
- 2022/23
- Learning activities
- Caratterizzante
- Area
- Discipline chimiche, farmaceutiche e tecnologiche
- Academic discipline
- CHIM/08
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa monodisciplinare
- Language of instruction
- Italian. Some slides and notes will be in English.
- Contents
- Drug identification via chemical, spectroscopic, polarimetric, rifractometric and chromatographic analyses according to the European Pharmacopoeia procedures. High performance liquid chromatography (HPLC): principles of liquid chromatography, chromatographic parameters, HPLC instrumentation, scale-up from analytical to preparative scale analysis, quantitative aspects.
- Reference texts
- V. Cavrini, V. Andrisano "Analisi Farmaceutica" Esculapio Ed.
A. Carta, M. G. Mamolo, F. Novelli, S. Piras "Analisi Farmaceutica Qualitativa" EdiSES Ed.F.
Savelli, O. Bruno "Analisi chimico-farmaceutica" Piccin-Nuova Libr. Ed.
E. Camaioni "Compendio teorico-pratico di analisi farmaceutica" Bertoni Ed.
Italian and European Pharmacopoeia. - Educational objectives
- Knowledge of basic and advanced analytical techniques to perform a quantitative analysis of a drug. Ability to recognize and to apply techniques and methodologies necessary for the development of a rational path that identifies a substance of pharmaceutical interest. Ability, based on experimental results, to interpret the information obtained and evaluate the results. Ability to use the specific language of this discipline and to present the results obtained and the methodologies used in a report clear, comprehensive and meaningful to describe the problem completely. Ability to update and expand their knowledge by consulting other library materials such as books and scientific publications.
- Prerequisites
- Knowledge of of the theoretical basis of Organic Chemistry (mandatory), Medicinal Chemistry (optional), Physical Methods in Organic Chemistry (mandatory) and Analytical Chemistry (important).
- Teaching methods
- Theoretical lessons and practical trainings. Attendance to the lessons and trainings is compulsory.
- Other information
- For practical trainings is mandatory to have passed the exam of "Metodi Fisici in Chimica Organica".
For further information about DSA: http://www.unipg.it/disabilita-e-dsa - Learning verification modality
- Lab practical exam and oral exam. Lab practical exam is done as lab experiments concerning the recognition and identification of two solid substances listed in the European Pharmacopoeia. This exam is mandatory to access to the oral exam.
Oral exam: consisting of open questions about the theoretical and practical aspects of the course with the aim to assess the level of preparation, the knowledge and understanding of the student. Online registration (esse3) is nedeed. - Extended program
- Introduction. Characters: physical state, solubility: definition, expression, factors that influence the solubility: temperature, purity, chemical nature and structure. Calcination of inorganic, metal-organic and organic substances. Systematic analysis of pharmaceutical inorganic substances. Elemental analysis: detection of carbon and hydrogen; Lassaigne test: detection of sulfur, nitrogen, halogens, and phosphorus; Beilstein test. Systematic analysis of pharmaceutical organo-metallic substances. Systematic analysis of pharmaceutical organic substances: solubility in water, ethyl ether, acids and bases. Functional group analysis: alcohols, phenols, aldehydes and ketones, amides, amines, nitrates and guanidine derivatives. Recognition of acetates, benzoates, salicylates, citrates, lactates, gluconates, tartrates. Specific tests for carbohydrates, polyalcohols, sulfonamides, xanthines, amino acids, parabens, quinoline derivatives, saccharin and others. Determination of physico-chemical constants: melting and boiling points, density and viscosity. Refractometric analysis: refractive index, Snell's law, Abbè Refractometer, applications. Polarimetric analysis: polarimeter, optical activity measurement, applications. IR-ATR spectroscopy. UV absorption spectrophotometry: instrumentation, Beer-Lambert law, qualitative and quantitative applications. Overview of concepts of quality control. High performance liquid chromatography (HPLC): principles of liquid chromatography, chromatographic parameters, HPLC instrumentation, scale-up from analytic to preparative scale analysis, quantitative aspects. Chromatographic separations of optically active compounds. Analysis for biopharmaceuticals.