Unit SYSTEMIC PATHOLOGY V
- Course
- Medicine and surgery
- Study-unit Code
- GP004561
- Location
- PERUGIA
- Curriculum
- In all curricula
- CFU
- 12
- Course Regulation
- Coorte 2022
- Offered
- 2025/26
- Type of study-unit
- Obbligatorio (Required)
- Type of learning activities
- Attività formativa integrata
BLOOD DISEASES - MOD. 1
| Code | GP004621 |
|---|---|
| Location | PERUGIA |
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Sector | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
- Language of instruction
- Italian
- Contents
- The myeloproliferative syndromes: - Chronic myeloid leukemia - Idiopathic myelofibrosis - Polycythemia Vera - Essential thrombocythemia The myelodysplastic syndromes The acute leukemias - Acute myeloid and lymphoid leukemias - Classification and clinical presentation. - Key molecular alterations associated - Examples of 'target' therapy Chronic lymphoproliferative disorders: - Chronic lymphocytic leukemia - The hairy cell leukemia The malignant lymphomas - Hodgkin's disease - Non-Hodgkin's Lymphoma The monoclonal gammopathy - MGUS - Multiple Myeloma - Waldenstrom's Macroglobulinemia
- Reference texts
- Harrison's - Principles of Internal Medicine Hoffbrand/Moss - Essential Haematology Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue Avvisati – Ematologia di Mandelli Hoffman - Hematology basic principles and practice
- Educational objectives
- The learning outcomes are compliant with the provisions in the didactic published at: http: //www.med.unipg.it/ccl (http://www.med.unipg.it/ccl) In detail, the general objective of education is to provide students with the foundation to address the study of blood diseases (either malignant or not).
- Prerequisites
- In order to understand and know how to tackle the course, students must have the basic understanding on: - Physiology of blood, features and functions of the elements of blood (leukocytes, erythrocytes and platelets) - Anatomy, organization and functions of the lymphatic system - Cellular and humoral immunity - Structure of the bone marrow and hematopoiesis - The blood count - Principles of Serum protein electrophoresis - The monoclonal antibodies
- Teaching methods
- Face to face lessons. Clinical cases discussion.
- Learning verification modality
- METHOD OF CONDUCTING THE EXAM: oral test (lasting about 15-20 minutes) will be assessed the acquired knowledge and the student's ability to communicate and reason confronted with a specific question. The oral exam consists of a discussion-interview on the topics covered during the course or at least in the program and in-depth texts Recommended. For Blood Diseases Teaching a topic of oncohematology and non malignant disease will be addressed. TESTING OF CLINICAL SKILLS: interpretation of a blood count, discussion of a clinical case. METHOD OF ALLOCATION OF THE FINAL MARK: arithmetic average of the marks obtained in the individual disciplines
- Extended program
- The myeloproliferative syndromes: - Chronic myeloid leukemia - Idiopathic myelofibrosis - Polycythemia Vera - Essential thrombocythemia The myelodysplastic syndromes The acute leukemias - Acute myeloid and lymphoid leukemias - Classification and clinical presentation. - Key molecular alterations associated - Examples of 'target' therapy Chronic lymphoproliferative disorders: - Chronic lymphocytic leukemia - The hairy cell leukemia The malignant lymphomas - Hodgkin's disease - Non-Hodgkin's Lymphoma The monoclonal gammopathy - MGUS - Multiple Myeloma - Waldenstrom's Macroglobulinemia
Cognomi M-Z
- CFU
- 2
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
- Language of instruction
- Italian
- Contents
- The myeloproliferative syndromes: - Chronic myeloid leukemia - Idiopathic myelofibrosis - Polycythemia Vera - Essential thrombocythemia The myelodysplastic syndromes The acute leukemias - Acute myeloid and lymphoid leukemias - Classification and clinical presentation. - Key molecular alterations associated - Examples of 'target' therapy Chronic lymphoproliferative disorders: - Chronic lymphocytic leukemia - The hairy cell leukemia The malignant lymphomas - Hodgkin's disease - Non-Hodgkin's Lymphoma The monoclonal gammopathy - MGUS - Multiple Myeloma - Waldenstrom's Macroglobulinemia
- Reference texts
- Harrison's - Principles of Internal Medicine Hoffbrand/Moss - Essential Haematology Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue Avvisati – Ematologia di Mandelli Hoffman - Hematology basic principles and practice
- Educational objectives
- The learning outcomes are compliant with the provisions in the didactic published at: http: //www.med.unipg.it/ccl (http://www.med.unipg.it/ccl) In detail, the general objective of education is to provide students with the foundation to address the study of blood diseases (either malignant or not).
- Prerequisites
- In order to understand and know how to tackle the course, students must have the basic understanding on: - Physiology of blood, features and functions of the elements of blood (leukocytes, erythrocytes and platelets) - Anatomy, organization and functions of the lymphatic system - Cellular and humoral immunity - Structure of the bone marrow and hematopoiesis - The blood count - Principles of Serum protein electrophoresis - The monoclonal antibodies
- Teaching methods
- Face to face lessons. Clinical cases discussion.
- Learning verification modality
- METHOD OF CONDUCTING THE EXAM: oral test (lasting about 15-20 minutes) will be assessed the acquired knowledge and the student's ability to communicate and reason confronted with a specific question. The oral exam consists of a discussion-interview on the topics covered during the course or at least in the program and in-depth texts Recommended. For Blood Diseases Teaching a topic of oncohematology and non malignant disease will be addressed. TESTING OF CLINICAL SKILLS: interpretation of a blood count, discussion of a clinical case. METHOD OF ALLOCATION OF THE FINAL MARK: arithmetic average of the marks obtained in the individual disciplines
- Extended program
- The myeloproliferative syndromes: - Chronic myeloid leukemia - Idiopathic myelofibrosis - Polycythemia Vera - Essential thrombocythemia The myelodysplastic syndromes The acute leukemias - Acute myeloid and lymphoid leukemias - Classification and clinical presentation. - Key molecular alterations associated - Examples of 'target' therapy Chronic lymphoproliferative disorders: - Chronic lymphocytic leukemia - The hairy cell leukemia The malignant lymphomas - Hodgkin's disease - Non-Hodgkin's Lymphoma The monoclonal gammopathy - MGUS - Multiple Myeloma - Waldenstrom's Macroglobulinemia
BLOOD DISEASES - MOD. 2
| Code | GP004622 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Sector | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 12.5 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 12.5 ore - Antonio Pierini
DISEASES OF THE IMMUNE SYSTEM
| Code | GP005656 |
|---|---|
| Location | PERUGIA |
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Medicina delle attività motorie e del benessere |
| Sector | MED/09 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 2
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
MOLECULAR MEDICINE
| Code | GP004623 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Caratterizzante |
| Area | Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica |
| Sector | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 12.5 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression
Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system). - Reference texts
- The material will be provided by professor.
- Educational objectives
- Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
- Prerequisites
- Basic concepts of molecular biology.
- Teaching methods
- Frontal lessons;
Seminars. - Other information
- None.
- Learning verification modality
- Multiple choice quiz or oral exam.
- Extended program
- Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets.
Characteristics of leukemic and cancer stem cell
Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes.
Intratumoral heterogeneity, clonality, and subclonality of genomic alterations.
Oncogenes and oncosuppressors: role and type of deregulation.
Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels.
Patterns of pathogenesis of congenital and acquired bone marrow failure.
Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms.
Pathogenesis models of Multiple Myeloma and Lymphomas.
Patterns of pathogenesis of solid tumors (central nervous system). - Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
Cognomi M-Z
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 12.5 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Technological approaches for genome study: cytogenetics, molecular cytogenetics, microarrays, NGS, WET assay. Leukemic and cancer stem cells, multistep process of oncogenesis; mechanisms of deregulation of oncogenes, oncosuppressors, repair genes and check-point genes. Basic principles of epigenetic regulation in DNA transcription and gene expression
Hematopietic clonality, clonal hematopoiesis and human diseases, and pathogenesis of leukemias. Pathogenesis models of congenital and acquired bone marrow failures. Patterns of pathogenesis of acute leukemias. Function of tyrosine kinases. Models of pathogenesis of lymphoproliferative disorders. Models of pathogenesis of myeloma. Patterns of pathogenesis of solid tumors (central nervous system). - Reference texts
- The material will be provided by professor.
- Educational objectives
- Learning study approaches for genetic and epigenetic characterization of blood diseases. Fundamental basis for understanding the processes of oncogenesis of major hematologic cancers.
- Prerequisites
- Basic concepts of molecular biology.
- Teaching methods
- Frontal lessons;
Seminars. - Other information
- None.
- Learning verification modality
- Multiple choice quiz or oral exam.
- Extended program
- Technological approaches for genome study: conventional cytogenetics, fluorescence in situ hybridization (interphase, metaphase, on tissue), multi-FISH, arrays on DNA and RNA, NGS targets.
Characteristics of leukemic and cancer stem cell
Study of the multistep process of oncogenesis, mechanisms of alteration of oncogenes, oncosuppressors, repair genes and check-point genes.
Intratumoral heterogeneity, clonality, and subclonality of genomic alterations.
Oncogenes and oncosuppressors: role and type of deregulation.
Principles of epigenetic regulation, both at the transcriptional and post-transcriptional levels.
Patterns of pathogenesis of congenital and acquired bone marrow failure.
Patterns of pathogenesis of Acute and chronic Leukemias. Function and involvement of tyrosine kinases in human neoplasms.
Pathogenesis models of Multiple Myeloma and Lymphomas.
Patterns of pathogenesis of solid tumors (central nervous system). - Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
REUMATHOLOGY
| Code | GP005657 |
|---|---|
| Location | PERUGIA |
| CFU | 2 |
| Learning activities | Caratterizzante |
| Area | Clinica delle specialità medico-chirurgiche |
| Sector | MED/16 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 2
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci
Cognomi M-Z
- CFU
- 2
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci
PROFESSIONALISING TRAINING IN BLOOD DISEASES
| Code | GP004624 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Sector | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
Cognomi M-Z
- CFU
- 1
- Teacher
- Maria Paola Martelli
- Teachers
- Maria Paola Martelli
- Hours
- 25 ore - Maria Paola Martelli
- Language of instruction
- Italian
- Contents
- Activities in the outpatient and clinic department with the specialist: General approach to the patient with alteration of CBC Discussion of normal and abnormal blood counts: anemia and erythrocytosis leucopenie and leukocytosis thrombocytopenia and thrombocytosis pancytopenia General approach to the patient with lymphadenopathy General approach to the patient with splenomegaly - Execution, staining and reading the smear of peripheral venous blood (SVP) - Vision and participation in the examination of the bone marrow: bone marrow aspiration and biopsy procedures
- Reference texts
- Harrison's - Principles of Internal Medicine Hoffbrand/Moss - Essential Haematology Bosi, De Stefano, Di Raimondo, La Nasa – Manuale di Malattie del Sangue Avvisati – Ematologia di Mandelli Hoffman - Hematology basic principles and practice
- Educational objectives
- The learning outcomes are compliant with the provisions in the didactic published at: http: //www.med.unipg.it/ccl (http://www.med.unipg.it/ccl) In detail, the general objective of education is to provide students with the foundation to address the study of blood diseases (either malignant or not). Prerequisiti Avvenuta frequenza corso Malattie del Sangue Metodi didattici Esercitazioni in reparto/Ambulatorio e laboratorio Altre informazioni Sede: Reparto/Day Hospital Ematologia - Ospedale Santa Maria della Misericordia-Perugia Modalità di verifica dell'apprendimento Discussione caso clinico. Prova pratica in reparto. Discussione su percorsi di diagnosi differenziale Programma esteso - Attività clinica in ambulatorio/reparto con lo specialista: Approccio generale al paziente con alterazione dell’emocromo Discussione di esami emocromocitometrici normali e alterati: anemie e eritrocitosi leucopenie e leucocitosi piastrinopenie e piastrinosi pancitopenie Approccio generale al paziente con linfoadenomegalia Approccio generale al paziente con splenomegalia - Esecuzione, colorazione e lettura dello striscio di sangue venoso periferico (SVP) - Visione e partecipazione all’esame del midollo osseo: aspirato midollare e biopsia osteomidollare Obiettivi per lo sviluppo sostenibile Codice Descrizione The main skills that will be acquired: - Analyze a CBC - Identify the diagnostic procedure for alterations in the numbers of blood elements - Identify the diagnostic procedure in case of lymphadenopathy - Identify the diagnostic procedure in case of splenomegaly
- Prerequisites
- Blood Diseases course attendance
- Teaching methods
- Clinic department and laboratory attendance
- Other information
- Hematology Department / Day Hospital - Santa Maria della Misericordia Hospital –Perugia
- Learning verification modality
- Clinical case discussion. Practice test in the department. Discussion on differential diagnosis paths
- Extended program
- Activities in the outpatient and clinic department with the specialist: General approach to the patient with alteration of CBC Discussion of normal and abnormal blood counts: anemia and erythrocytosis leucopenie and leukocytosis thrombocytopenia and thrombocytosis pancytopenia General approach to the patient with lymphadenopathy General approach to the patient with splenomegaly - Execution, staining and reading the smear of peripheral venous blood (SVP) - Vision and participation in the examination of the bone marrow: bone marrow aspiration and biopsy procedures
PROFESSIONALISING TRAINING IN DISEASES OF THE IMMUNE SYSTEM
| Code | GP005658 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Sector | MED/09 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
Cognomi M-Z
- CFU
- 1
- Teacher
- Antonio Pierini
- Teachers
- Antonio Pierini
- Hours
- 25 ore - Antonio Pierini
PROFESSIONALISING TRAINING IN MOLECULAR MEDICINE
| Code | GP004625 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Sector | MED/15 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 25 ore - Roberta La Starza
- Language of instruction
- Italian
- Contents
- Introduction to technologies used to study the genome, DNA methylation, and histone methylation. Protocols and their applications. Diagnostic algorithms aimed at classification of human malignancies and identification of diagnostic and predictive markers.
- Reference texts
- None.
- Educational objectives
- Ability to address diagnostic investigations and optimize procedures.
- Prerequisites
- Knowledge of the genetic basis of tumors.
- Teaching methods
- Tutor system in working groups.
- Other information
- None.
- Learning verification modality
- During the exam.
- Extended program
- Conventional cytogenetics. FISH, SNPa, RNA microarray, PCR, sequencing, sanger sequencing and NGS. Telomeres, Chromosomal instability test. Test on paraffin sections. Nucleic acids, separation. Microarrays.
- Obiettivi Agenda 2030 per lo sviluppo sostenibile
- 3 - Health
Cognomi M-Z
- CFU
- 1
- Teacher
- Roberta La Starza
- Teachers
- Roberta La Starza
- Hours
- 25 ore - Roberta La Starza
PROFESSIONALISING TRAINING IN REUMATHOLOGY
| Code | GP005659 |
|---|---|
| Location | PERUGIA |
| CFU | 1 |
| Learning activities | Altro |
| Area | Tirocini formativi e di orientamento |
| Sector | MED/16 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
- CFU
- 1
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci
Cognomi M-Z
- CFU
- 1
- Teacher
- Elena Bartoloni Bocci
- Teachers
- Elena Bartoloni Bocci
- Hours
- 25 ore - Elena Bartoloni Bocci