Unit PHARMACOLOGICAL SCIENCES

ELEMENTS OF CLINICAL PHARMACOLOGY

Code	A001523
CFU	1
Teacher	Alessandro D'arpino
Teachers	Sara Pugliese (Codocenza) Alessandro D'arpino
Hours	4 ore (Codocenza) - Sara Pugliese 8 ore - Alessandro D'arpino
Learning activities	Caratterizzante
Area	Scienze della prevenzione e dei servizi sanitari
Sector	MED/50
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Elements of pharmacology, technique and pharmaceutical legislation applied operationally in a Hospital Pharmacy lab of Clinical Galenica
Reference texts	Slides projected in class. Paths, materials and/or assessment methodologies consistent with the needs of students with disabilities and/or specific learning disorders (SLD) are planned.
Educational objectives	The course aims to provide students with the knowledge bases of the clinical needs underlying the main galenic and pharmaceutical preparations including the preparation of antiblastics and the related implications in terms of treatment safety. The knowledge provided by the module will be the basis for understanding the contents of the Pharmacology Methods and Techniques module
Prerequisites	“General chemistry and chemistry laboratory” (1st year, 1st semester) is preparatory
Teaching methods	Frontal lessons. Paths, materials and/or assessment methodologies consistent with the needs of students with disabilities and/or specific learning disorders (SLD) are planned.
Other information	Teachers are available to receive students upon request via email
Learning verification modality	Learning is verified through an oral test carried out at the same time as the other modules of the same course. Paths, materials and/or assessment methodologies consistent with the needs of students with disabilities and/or specific learning disorders (SLD) are planned.
Extended program	Oncological galenics: the tumor, main classes of oncological drugs and routes of administration, definitions, regulatory references/scientific society documents/guidelines, personal, rooms/environments, preparation procedures and methods, sterility, exposure of personnel and collective/individual protective equipment. Neonatal parenteral nutrition. Oral pharmaceutical forms (capsules, suspensions) Eye drops

PHARMACY TOXICOLOGY

Code	A001521
CFU	1
Teacher	Simona Ronchetti
Teachers	Simona Ronchetti
Hours	12 ore - Simona Ronchetti
Learning activities	Base
Area	Primo soccorso
Sector	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	italian
Contents	Toxicology: general principlesDrug adverse reactionsantidotesdrug-drug interaction, drug-food interactionspre-clinical and clinical trials
Reference texts	- F. Rossi, V. Cuomo, C. Riccardi, Farmacologia: principi di base e applicazioni terapeutiche, III Edizione, Edizioni Minerva Medica ¿- Rang, Dale, Ritter, Flower. Farmacologia-C.L. Galli, E. Corsini, M. Marinovich, Tossicologia, Piccin There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students
Educational objectives	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicitydrug adverse reactions: classification and examplesantidotes: the most important for poisoningdrug-drug interaction, drug-food interactionspre-clinical and clinical trials
Prerequisites	basic principle of general chemistry
Teaching methods	The lessons are frontal, with direct interaction and occasionally discussions on the topic, with examples drawn from the practical activity of a laboratory technician. There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students
Other information	Compulsory course attendance. Office hours: fridays 12-13
Learning verification modality	Oral exam, with 2 questions to be answered in 7-8 minutes There are planned pathways, materials, and/or assessment methodologies consistent with the needs of disabled and/or DSA students. Please visit the web site on http://www.unipg.it/disabilita-e-dsa
Extended program	Toxicology: general principles, dose-toxic effect relationship, toxicity curves, organ toxicity drug adverse reactions: classification and examplesantidotes: the most important for poisoning. Drug-drug interaction, drug-food interactions, pre-clinical and clinical trials
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Health and wellness

GENERAL PHARMACOLOGY

Code	A001520
CFU	2
Teacher	Maria Teresa Pallotta
Teachers	Maria Teresa Pallotta
Hours	24 ore - Maria Teresa Pallotta
Learning activities	Base
Area	Primo soccorso
Sector	BIO/14
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	General principles of Pharmacology. Pharmacodynamics: drug receptors and receptors/mechanisms. Pharmacokinetics: disposition and metabolisms of drugs. Drug development, evaluation of new drugs and principles of therapeutics. Pharmacology for special patient populations.
Reference texts	R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli - Farmacologia generale e molecolare. Moreover, the presentations used during the class are available to the student and can be downloaded from Unistudium. Appropriate learning pathways, materials, and assessment methods are available to meet the needs of students with disabilities and/or specific learning disorders (SLD).
Educational objectives	The General Pharmacology module aims to provide students with the fundamental knowledge of the principles governing the interaction between drugs and the organism, with particular emphasis on the mechanisms underlying pharmacological action, the dose–effect relationship, and the processes that determine the efficacy and safety of treatments. The study of pharmacokinetic and pharmacodynamic principles will enable students to understand the fate of drugs in the organism, the molecular and cellular mechanisms underlying pharmacological effects, and the main parameters used for the evaluation of drug activity. These skills are closely related to the professional role of the Biomedical Laboratory Scientist, who operates in the fields of diagnostics and biomedical research, contributing to the correct execution, interpretation, and evaluation of analytical and experimental procedures, including those related to the study of drugs and their biological effects. In particular, students will acquire knowledge of: drug absorption, distribution, metabolism, and elimination; routes of administration, bioavailability, and bioequivalence; pharmacological receptors, receptor activation theories, and signal transduction mechanisms; dose–response relationships, pharmacological efficacy, and toxic effects. At the end of the module, students will be able to: understand the main mechanisms of drug action and their relationship with the molecular targets involved; interpret the main pharmacokinetic and pharmacodynamic parameters; correlate drug dose with pharmacological response; apply general pharmacology knowledge to the understanding of laboratory methods related to the study of drugs and their biological effects.
Prerequisites	The student must have knowledge of anatomy, physiology and general pathology. The student must also comply with the required prerequisite.
Teaching methods	Lectures on all the topics of the course. Appropriate learning pathways, materials, and assessment methods are available to meet the needs of students with disabilities and/or specific learning disorders (SLD).
Other information	For further information or to arrange an appointment, please contact the Professor at maria.pallotta@unipg.it
Learning verification modality	The examination consists of an oral exam lasting approximately 15 minutes, during which candidates will be asked two questions: one on pharmacokinetics and one on pharmacodynamics. The test is aimed at ascertaining the level of knowledge and understanding get by the student on the the course program. Through the oral test, the teacher will also verify the language skills and student's ability to organize the argument. Appropriate learning pathways, materials, and assessment methods are available to meet the needs of students with disabilities and/or specific learning disorders (SLD).
Extended program	Definition of drug. Features of the conventional drug. Natural and synthetic drugs. Biodrugs and biotechnological drugs. Primary, side, unwanted and toxic effects. Cellular basis of pharmacokinetics (cell barriers and drug transport across membranes). Absorption and routes of drug administration. Distribution, metabolism and elimination of drugs. Interaction between drugs. Pharmacodynamics: receptors and receptor activation theories. Definition of agonist, antagonist and allosteric modulator. Methods to study the biological responses of a drug, dose-response curves, potency and efficacy of a drug. Binding studies and definition of drug affinity. Classes of receptors (G-protein coupled receptor, ionic receptor, receptor associated with an enzymatic activity, intracellular receptor). Mechanisms of signal transduction
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Health and wellbeing

PHARMACOLOGY AND TOXICOLOGY METHODS AND TECHNIQUES

Code	A001522
CFU	1
Teacher	Tiziana Chiocci
Learning activities	Caratterizzante
Area	Scienze e tecniche di laboratorio biomedico
Sector	MED/46
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italiano
Contents	• Galenica sterile e non sterile, procedure preparatorie, relative norme e strumentazioni • Norme di buona preparazione, DPI e DMC • Allestimento farmaci antineoplastici e automazione del processo • Preparazione Sacche Nutrizione Parenterale e automazione del processo • Percorso formativo ed addestramento del tecnico sanitario di laboratorio biomedico nella Farmacia Ospedaliera acquisizione di principi teorici e di tecniche lavorative nel campo della farmacia Ospedaliera
Reference texts	Materiale fornito durante le lezioni e relativi appunti
Educational objectives	Conoscenza dei metodi di preparazione di galenica sterile, allestimento personalizzato di antiblastici, galenica non sterile e nutrizione parenterale. Conoscenza delle norme di buona preparazione applicate alle rispettive aree di lavoro.
Teaching methods	Lezioni frontali integrate a lezioni in laboratorio.
Learning verification modality	Esame orale
Extended program	1 PREPARAZIONE ANTIBLASTICI Laboratorio U.F.A, utilizzo DPI e DPC. allestimento antiblastici in diverse modalità (manuale, semiautomatica e automatica), norme di buona preparazione, convalide di processo. 2 PREPRAZIONE NUTRIZIONE PARENTERALE Procedure operative per l'allestimento di una sacca di nutrizione parenterale, convalide di processo. 3 PREPARATI OCULARI Preparazioni oftalmiche e allestimento di siringhe per iniezioni intravitreali. 4 GALENICA NON STERILE Procedure operative e norme di buona preparazione per l'allestimento di preparati di galenica non sterile (cartine,capsule,soluzioni,sospensioni orali, creme ed unguenti).