Unit BIOLOGY-PHYSIC AND STATISTICS

BIOCHEMISTRY

Code	GP003916
CFU	1
Teacher	Lara Macchioni
Teachers	Lara Macchioni
Hours	12 ore - Lara Macchioni
Learning activities	Base
Area	Scienze biomediche
Sector	BIOS-07/A
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Functional groups of organic molecules. Molecules of biological interest. Metabolic pathways. Krebs cycle. Respiratory chain. Oxidative phosphorylation. Metabolism of carbohydrates, lipids, and aminoacids: the hormonal control of metabolism
Reference texts	Biochimica e Biologia per le Professioni Sanitarie - Rita Roberti, Giovanni Alunni Bistocchi, Cinzia Antognelli e Vincenzo Nicola Talesa - Mcgraw-hill Editor
Educational objectives	The main aim of this course is to provide students with the knowledge of basic properties of biological systems and of the mechanisms controlling cellular homeostasis. The main competence will be: -to evaluate the nature and properties of reagents and solutions usually employed in professional practice; - to understand the general metabolic behavior in physiopathological conditions.
Prerequisites	For an effective understanding of the topics of this integrated course, composed of Biochemistry, Applied biology, Physics and Medical Statistics, the basic knowledge at high school level of Chemistry, Biology, Physics and Statistics is required. In particular, general knowledge of cell structure, atomic structure, simple inorganic and organic molecules structure, and basic concepts of classical physics and statistics, are mandatory.
Teaching methods	The course is organized in lectures on all the subjects. Students are stimulated to interact with the teacher during the lectures.
Other information	See web site http://www.med.unipg.it/logopedia/
Learning verification modality	he exam consists of a written test and/or an oral examination relative to the four modules of the integrated course. The written test, comprising basic questions covering all the topics, aims to assess the minimum basic preparation to face the oral examination. The oral exam aims to assess the level of knowledge of the subjects of the integrated course, and the ability to make connections and to integrate knowledge. The oral exam will also test the student communication skills. The final evaluation takes into account mainly the oral exam.
Extended program	ELEMENTS OF GENERAL BIOCHEMISTRY. Carbohydrates. Structure and properties of monosaccharides, disaccharides, and polysaccharides. The glycosidic bond. Carbohydrates of physiologic significance: glucose, fructose, ribose, saccharose, lactose, starch, cellulose, glycogen. Lipids. Structure and properties of fatty acids, acylglycerols, phospholipids, glycolipids, and cholesterol. Aminoacids. Proteins: structural organization, classification, functions. Denaturation of proteins. Structure and functions of hemoglobin and myoglobin. Oxygen transport. ELEMENTS OF DYNAMIC BIOCHEMISTRY. Overview of metabolic pathways: anabolism, catabolism, linear and cyclic pathways. ATP: structure and role in the metabolism. The Krebs cycle. The respiratory chain and oxidative phosphorylation. The metabolism of carbohydrates. Digestion and absorption of sugars. Glycolysis and metabolism of glycogen. The hormonal control of blood glucose (insulin and glucagon). The metabolism of fats. Digestion, absorption, and storage of dietary lipids. Lipolysis and fatty acid oxidation. Biosynthesis of fatty acids and triacylglycerols. Hormonal control of lipolysis and lipogenesis (insulin and glucagon). The ketone bodies. The metabolism of proteins and aminoacids. Protein digestion and aminoacid absorption. Transamination and deamination reactions. Ureogenesis. The metabolic fate of aminoacid carbon skeleton.
Obiettivi Agenda 2030 per lo sviluppo sostenibile	Health and wellness

APPLIED BIOLOGY

Code	GP003915
CFU	2
Teacher	Rita Romani
Teachers	Rita Romani
Hours	24 ore - Rita Romani
Learning activities	Base
Area	Scienze biomediche
Sector	BIOS-10/A
Type of study-unit	Obbligatorio (Required)
Language of instruction	Italian
Contents	Biological and chemical basis of life and molecular organization. Structure and function of the plasma membrane. Cell wall and extracellular matrix: structure, function and interaction of cells with the extracellular environment and cells between them. Cell communication: cell signaling and signal transduction. Cytoplasmic membrane systems: structure, function, and membrane trafficking. The mitochondria and cellular respiration. Cancer. General genetics.Tumor cells: development and progression mechanisms of tumors
Reference texts	Biologia e Genetica EDISES autori De Leo, Ginellli, Fasano - L'essenziale di biologia molecolare della cellulaAlberts B., Johnson A.,Lewis J., et al. Zanichelli -"Elementi di Biologia e Genetica"WK Purves, D Sadava, GH Orians, HC Heller . Zanichelli - Fondamenti di Biologia Solomon; Martin; Martin; Berg casa editrice EdiSES
Educational objectives	Objective of the course is the integrated study of the cell and of living organisms, with particular regard to the mechanisms involved in the biogenesis of organelles and cellular structures, interactions between cells and between cells and the extracellular environment, synthesis and transmission of genetic information, gene expression mechanisms, cell proliferation, bases of genetics.
Prerequisites	To achieve the training objectives, the student requires a minimum knowledge of Chemistry
Teaching methods	Face-to-face theoretical lessons with the use of powerpoint slides
Other information	For information on support services for students with disabilities and / or DSA visit the page http://www.unipg.it/disabilita-e-dsa
Learning verification modality	The examination is a written test, aimed at ascertaining the student's achieved understanding of the theoretical and methodological content of the program For information on support services for students with disabilities and/or DSA, visit http://www.unipg.it/disabilita-e-dsa
Extended program	The biological organization. Characteristics of living organisms. Prokaryotic and eukaryotic cells. Virus. The chemical basis of life. Biological macromolecules: proteins, nucleic acids, lipids, carbohydrates. The cell membrane: structure and function with particular reference to transport mechanisms and cellular communication. The various types of receptors and signal transduction pathways. The nucleus and nucleolus: structure and function. Organization of chromatin, chromosomes. Characteristics of the eukaryotic gene. Gene expression: transcription and its regulation. Editing of primary transcripts. Gene expression: Characteristics of the genetic code and its operation. Translation and its control. Smooth and rough endoplasmic reticulum. Golgi apparatus, lysosomes and peroxisomes. Vesicle trafficking and sorting of proteins. The mitochondria and cellular respiration. Cell cycle and its control. Interphase, DNA replication, mitosis. Mutations. Oncogenes and tumor suppressor. Reproduction of multicellular organisms: Meiosis and gametogenesis. Definitions and meaning of a gene locus, allele, haploid, diploid genotype, phenotype, homozygous, heterozygous, dominant and recessive. Mendel's laws and their interpretation. Extensions to Mendelian analysis. Inheritance: generality and mode of transmission. Normal and pathological human karyotypeTumor cells: development and progression mechanisms of tumors; crucial genes for cancer (oncogenes and oncosuppressor genes, retroviral genes, Ras, Rb, p53).
Obiettivi Agenda 2030 per lo sviluppo sostenibile	health and wellness

APPLIED PHYSICS

Code	GP003918
CFU	2
Teacher	Fabrizio Napolitano
Teachers	Fabrizio Napolitano
Hours	20 ore - Fabrizio Napolitano
Learning activities	Base
Area	Scienze propedeutiche
Sector	PHYS-06/A
Type of study-unit	Obbligatorio (Required)

MEDICAL STATISTICS

Code	GP003917
CFU	2
Teacher	Fabrizio Stracci
Teachers	Fabrizio Stracci
Hours	20 ore - Fabrizio Stracci
Learning activities	Base
Area	Scienze propedeutiche
Sector	MEDS-24/A
Type of study-unit	Obbligatorio (Required)