| Code |
50A00166 |
| CFU |
2 |
| Teacher |
Rita Romani |
| Teachers |
|
| Hours |
|
| Learning activities |
Base |
| Area |
Scienze biomediche |
| Sector |
BIOS-10/A |
| Type of study-unit |
Obbligatorio (Required) |
| Language of instruction |
Italian |
| Contents |
Biological and chemical basis of life and molecular organization. Structure and function of the plasma membrane. Cell wall and extracellular matrix: structure, function and interaction of cells with the extracellular environment and cells between them. Cell communication: cell signaling and signal transduction. Cytoplasmic membrane systems: structure, function, and membrane trafficking. The mitochondria and cellular respiration. Cancer. General genetics.Tumor cells: development and progression mechanisms of tumors |
| Reference texts |
Biologia e Genetica EDISES autori De Leo, Ginellli, Fasano - L'essenziale di biologia molecolare della cellulaAlberts B., Johnson A.,Lewis J., et al. Zanichelli -"Elementi di Biologia e Genetica"WK Purves, D Sadava, GH Orians, HC Heller . Zanichelli - Fondamenti di Biologia Solomon; Martin; Martin; Berg casa editrice EdiSES |
| Educational objectives |
Objective of the course is the integrated study of the cell and of living organisms, with particular regard to the mechanisms involved in the biogenesis of organelles and cellular structures, interactions between cells and between cells and the extracellular environment, synthesis and transmission of genetic information, gene expression mechanisms, cell proliferation, bases of genetics. |
| Prerequisites |
To achieve the training objectives, the student requires a minimum knowledge of Chemistry |
| Teaching methods |
Face-to-face theoretical lessons with the use of powerpoint slides |
| Other information |
For information on support services for students with disabilities and / or DSA visit the page http://www.unipg.it/disabilita-e-dsa |
| Learning verification modality |
The examination is a written test, aimed at ascertaining the student's achieved understanding of the theoretical and methodological content of the program For information on support services for students with disabilities and/or DSA, visit http://www.unipg.it/disabilita-e-dsa |
| Extended program |
The biological organization. Characteristics of living organisms. Prokaryotic and eukaryotic cells. Virus. The chemical basis of life. Biological macromolecules: proteins, nucleic acids, lipids, carbohydrates. The cell membrane: structure and function with particular reference to transport mechanisms and cellular communication. The various types of receptors and signal transduction pathways. The nucleus and nucleolus: structure and function. Organization of chromatin, chromosomes. Characteristics of the eukaryotic gene. Gene expression: transcription and its regulation. Editing of primary transcripts. Gene expression: Characteristics of the genetic code and its operation. Translation and its control. Smooth and rough endoplasmic reticulum. Golgi apparatus, lysosomes and peroxisomes. Vesicle trafficking and sorting of proteins. The mitochondria and cellular respiration. Cell cycle and its control. Interphase, DNA replication, mitosis. Mutations. Oncogenes and tumor suppressor. Reproduction of multicellular organisms: Meiosis and gametogenesis. Definitions and meaning of a gene locus, allele, haploid, diploid genotype, phenotype, homozygous, heterozygous, dominant and recessive. Mendel's laws and their interpretation. Extensions to Mendelian analysis. Inheritance: generality and mode of transmission. Normal and pathological human karyotypeTumor cells: development and progression mechanisms of tumors; crucial genes for cancer (oncogenes and oncosuppressor genes, retroviral genes, Ras, Rb, p53). |
| Obiettivi Agenda 2030 per lo sviluppo sostenibile |
health and wellness |
